Operating Regimes of Signaling Cycles: Statics, Dynamics, and Noise Filtering

Carlos Gomez-Uribe; George C Verghese; Leonid A Mirny

doi:10.1371/journal.pcbi.0030246

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Open Access

Peer-reviewed

Research Article

Operating Regimes of Signaling Cycles: Statics, Dynamics, and Noise Filtering

Carlos Gomez-Uribe,

Affiliations Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America , Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
George C Verghese,

Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Leonid A Mirny

*To whom correspondence should be addressed. E-mail: leonid@mit.edu

Affiliation Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

Operating Regimes of Signaling Cycles: Statics, Dynamics, and Noise Filtering

Carlos Gomez-Uribe,
George C Verghese,
Leonid A Mirny

Published: December 21, 2007
https://doi.org/10.1371/journal.pcbi.0030246

About the Authors

Carlos Gomez-Uribe

Affiliations Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America , Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

George C Verghese

Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Leonid A Mirny

*To whom correspondence should be addressed. E-mail: leonid@mit.edu

Affiliation Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CGU, GCV, and LAM conceived and designed the experiments. CGU and LAM performed the experiments. All authors analyzed the data and wrote the paper.

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Signal filtering
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Enzymes
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Phosphatases
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Signaling networks
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Phosphorylation
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Protein kinase signaling cascade
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Dynamic response
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MAPK signaling cascades
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