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Research Article

Analysis of Sequence Conservation at Nucleotide Resolution

  • Saurabh Asthana,

    Affiliation: Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mikhail Roytberg,

    Affiliation: Computational Biology Group, Institute of Mathematical Problems in Biology, Russian Academy of Sciences, Pushchino, Russia

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  • John Stamatoyannopoulos mail,

    To whom correspondence should be addressed. E-mail: ssunyaev@rics.bwh.harvard.edu (SS), jstam@u.washington.edu (JS)

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Shamil Sunyaev mail

    To whom correspondence should be addressed. E-mail: ssunyaev@rics.bwh.harvard.edu (SS), jstam@u.washington.edu (JS)

    Affiliation: Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: December 28, 2007
  • DOI: 10.1371/journal.pcbi.0030254

About the Authors

Saurabh Asthana, Shamil Sunyaev
Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Mikhail Roytberg
Computational Biology Group, Institute of Mathematical Problems in Biology, Russian Academy of Sciences, Pushchino, Russia
John Stamatoyannopoulos
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SA and SS conceived and designed the experiments. SA performed the experiments. SA and SS analyzed the data. MR and JS contributed reagents/materials/analysis tools. SA wrote the paper.