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Research Article

Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor

  • Xinli Liu,

    Affiliation: Department of Engineering Mechanics, State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, Liaoning, China

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  • Yechun Xu,

    Affiliation: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Honglin Li,

    Affiliation: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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  • Xicheng Wang mail,

    To whom correspondence should be addressed. E-mail: guixum@dlut.edu.cn (XW); hljiang@mail.shcnc.ac.cn (HJ)

    Affiliation: Department of Engineering Mechanics, State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, Liaoning, China

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  • Hualiang Jiang mail,

    To whom correspondence should be addressed. E-mail: guixum@dlut.edu.cn (XW); hljiang@mail.shcnc.ac.cn (HJ)

    Affiliations: Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Francisco J Barrantes

    Affiliation: UNESCO Chair of Biophysics & Molecular Neurobiology and Instituto de Investigaciones Bioquímicas de Bahía Blanca, Bahía Blanca, Argentina

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  • Published: January 25, 2008
  • DOI: 10.1371/journal.pcbi.0040019

About the Authors

Xinli Liu, Xicheng Wang
Department of Engineering Mechanics, State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, Liaoning, China
Yechun Xu, Honglin Li, Hualiang Jiang
Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Hualiang Jiang
School of Pharmacy, East China University of Science and Technology, Shanghai, China
Francisco J Barrantes
UNESCO Chair of Biophysics & Molecular Neurobiology and Instituto de Investigaciones Bioquímicas de Bahía Blanca, Bahía Blanca, Argentina

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XW and HJ conceived and designed the experiments. XL, YX, and HL performed the experiments and analyzed the data. XL, XW, HJ, and FJB wrote the paper.