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Research Article

Modeling Cancer Progression via Pathway Dependencies

  • Elena J Edelman,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America

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  • Justin Guinney,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America

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  • Jen-Tsan Chi,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina

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  • Phillip G Febbo equal contributor,

    equal contributor Contributed equally to this work with: Phillip G Febbo, Sayan Mukherjee

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Sayan Mukherjee equal contributor mail

    equal contributor Contributed equally to this work with: Phillip G Febbo, Sayan Mukherjee

    To whom correspondence should be addressed. E-mail: sayan@stat.duke.edu

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Statistical Science, Duke University, Durham, North Carolina, United States of America, Department of Computer Science, Duke University, Durham, North Carolina, United States of America

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  • Published: February 15, 2008
  • DOI: 10.1371/journal.pcbi.0040028

About the Authors

Elena J Edelman, Justin Guinney, Jen-Tsan Chi, Phillip G Febbo, Sayan Mukherjee
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
Elena J Edelman, Justin Guinney
Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina, United States of America
Jen-Tsan Chi, Phillip G Febbo
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina
Phillip G Febbo
Department of Medicine, Duke University, Durham, North Carolina, United States of America
Sayan Mukherjee
Department of Statistical Science, Duke University, Durham, North Carolina, United States of America
Sayan Mukherjee
Department of Computer Science, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: sayan@stat.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EJE analyzed the data and wrote the paper. JG contributed reagents/materials/analysis tools. JTC and PGF analyzed the data. SM conceived and designed the experiments and wrote the paper.