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Research Article

How Protein Stability and New Functions Trade Off

  • Nobuhiko Tokuriki,

    Affiliation: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

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  • Francois Stricher,

    Affiliation: EMBL-CRG Systems Biology Partnership Unit, CRG-Centro de Regulacion Genomica, Barcelona, Spain

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  • Luis Serrano,

    Affiliation: EMBL-CRG Systems Biology Partnership Unit, CRG-Centro de Regulacion Genomica, Barcelona, Spain

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  • Dan S. Tawfik mail

    tawfik@weizmann.ac.il

    Affiliation: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel

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  • Published: February 29, 2008
  • DOI: 10.1371/journal.pcbi.1000002

About the Authors

Nobuhiko Tokuriki, Dan S. Tawfik
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
Francois Stricher, Luis Serrano
EMBL-CRG Systems Biology Partnership Unit, CRG-Centro de Regulacion Genomica, Barcelona, Spain

Corresponding Author

Email: tawfik@weizmann.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NT DT. Performed the experiments: NT. Analyzed the data: NT. Contributed reagents/materials/analysis tools: FS LS. Wrote the paper: NT DT.