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Research Article

Multi-Scale Simulations Provide Supporting Evidence for the Hypothesis of Intramolecular Protein Translocation in GroEL/GroES Complexes

  • Ivan Coluzza mail,

    ic247@cam.ac.uk

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Alfonso De Simone,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Franca Fraternali,

    Affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom

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  • Daan Frenkel

    Affiliations: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom, FOM Institute AMOLF, Amsterdam, The Netherlands

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  • Published: February 29, 2008
  • DOI: 10.1371/journal.pcbi.1000006

About the Authors

Ivan Coluzza, Alfonso De Simone, Daan Frenkel
Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
Franca Fraternali
Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom
Daan Frenkel
FOM Institute AMOLF, Amsterdam, The Netherlands

Corresponding Author

Email: ic247@cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IC FF DF. Performed the experiments: IC ADS. Analyzed the data: IC ADS FF DF. Contributed reagents/materials/analysis tools: IC ADS FF DF. Wrote the paper: IC ADS FF DF.