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Research Article

Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation

  • Navin Elango equal contributor,

    equal contributor Contributed equally to this work with: Navin Elango, Seong-Ho Kim

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Seong-Ho Kim equal contributor,

    equal contributor Contributed equally to this work with: Navin Elango, Seong-Ho Kim

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    Current address: Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana

    X
  • NISC Comparative Sequencing Program,

    Affiliation: Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Eric Vigoda,

    Affiliation: College of Computing, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    X
  • Soojin V. Yi mail

    soojinyi@gatech.edu

    Affiliation: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

    X
  • Published: February 29, 2008
  • DOI: 10.1371/journal.pcbi.1000015

About the Authors

Navin Elango, Seong-Ho Kim, Soojin V. Yi
School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
NISC Comparative Sequencing Program
Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Eric Vigoda
College of Computing, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Corresponding Author

Email: soojinyi@gatech.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EV SY. Performed the experiments: NE SK NISC Comparative Sequencing Program EV SY. Analyzed the data: NE SK EV SY. Contributed reagents/materials/analysis tools: NISC Comparative Sequencing Program EV SY. Wrote the paper: EV SY.