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Research Article

Statistical Resolution of Ambiguous HLA Typing Data

  • Jennifer Listgarten mail,

    jennl@microsoft.com (JL); heckerma@microsoft.com (DH)

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • Zabrina Brumme,

    Affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Carl Kadie,

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • Gao Xiaojiang,

    Affiliation: SAIC-Frederick, National Cancer Institute, Frederick, Maryland, United States of America

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  • Bruce Walker,

    Affiliations: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Frederick, Maryland, United States of America

    X
  • Mary Carrington,

    Affiliation: SAIC-Frederick, National Cancer Institute, Frederick, Maryland, United States of America

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  • Philip Goulder,

    Affiliations: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Paediatrics, University of Oxford, Oxford, United Kingdom

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  • David Heckerman mail

    jennl@microsoft.com (JL); heckerma@microsoft.com (DH)

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

    X
  • Published: February 29, 2008
  • DOI: 10.1371/journal.pcbi.1000016

About the Authors

Jennifer Listgarten, Carl Kadie, David Heckerman
Microsoft Research, Redmond, Washington, United States of America
Zabrina Brumme, Bruce Walker, Philip Goulder
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Gao Xiaojiang, Mary Carrington
SAIC-Frederick, National Cancer Institute, Frederick, Maryland, United States of America
Bruce Walker
Howard Hughes Medical Institute, Frederick, Maryland, United States of America
Philip Goulder
Department of Paediatrics, University of Oxford, Oxford, United Kingdom

Corresponding Authors

Competing Interests

A tool based on our approach will be made freely available for research purposes at http://microsoft.com/science.

Author Contributions

JL contributed algorithm and experiment design, implementation and running of the experiments, and writing of the paper. ZLB organized the data and aided in the writing and experiment design. CK helped make the public Web tool version of the algorithm available. GX provided HLA typing of private data. BDW organized the data. MC provided HLA typing of private data, and aided in the writing. PJG presented the need for statistical HLA refinement. DH contributed algorithm and experiment design, and contributed to the writing of the paper.