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Research Article

Evaluation of Paired-End Sequencing Strategies for Detection of Genome Rearrangements in Cancer

  • Ali Bashir mail,

    abashir@ucsd.edu (AB); braphael@brown.edu (BJR)

    Affiliation: Bioinformatics Graduate Program, University of California San Diego, San Diego, California, United States of America

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  • Stanislav Volik,

    Affiliation: Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Colin Collins,

    Affiliation: Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

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  • Vineet Bafna,

    Affiliation: Department of Computer Science and Engineering, University of California San Diego, San Diego, California, United States of America

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  • Benjamin J. Raphael mail

    abashir@ucsd.edu (AB); braphael@brown.edu (BJR)

    Affiliation: Department of Computer Science and Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, United States of America

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  • Published: April 25, 2008
  • DOI: 10.1371/journal.pcbi.1000051

About the Authors

Ali Bashir
Bioinformatics Graduate Program, University of California San Diego, San Diego, California, United States of America
Stanislav Volik, Colin Collins
Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
Vineet Bafna
Department of Computer Science and Engineering, University of California San Diego, San Diego, California, United States of America
Benjamin J. Raphael
Department of Computer Science and Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB VB BR. Performed the experiments: AB. Analyzed the data: AB VB BR. Contributed reagents/materials/analysis tools: SV CC. Wrote the paper: AB VB BR.