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Research Article

Viral Population Estimation Using Pyrosequencing

  • Nicholas Eriksson mail,

    eriksson@galton.uchicago.edu (NE); niko.beerenwinkel@bsse.ethz.ch (NB)

    Affiliation: Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

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  • Lior Pachter,

    Affiliation: Department of Mathematics, University of California, Berkeley, California, United States of America

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  • Yumi Mitsuya,

    Affiliation: Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, United States of America

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  • Soo-Yon Rhee,

    Affiliation: Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, United States of America

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  • Chunlin Wang,

    Affiliation: Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, United States of America

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  • Baback Gharizadeh,

    Affiliation: Genome Technology Center, Stanford University, Palo Alto, California, United States of America

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  • Mostafa Ronaghi,

    Affiliation: Genome Technology Center, Stanford University, Palo Alto, California, United States of America

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  • Robert W. Shafer,

    Affiliation: Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, United States of America

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  • Niko Beerenwinkel mail

    eriksson@galton.uchicago.edu (NE); niko.beerenwinkel@bsse.ethz.ch (NB)

    Affiliation: Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

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  • Published: May 09, 2008
  • DOI: 10.1371/journal.pcbi.1000074

About the Authors

Nicholas Eriksson
Department of Statistics, University of Chicago, Chicago, Illinois, United States of America
Lior Pachter
Department of Mathematics, University of California, Berkeley, California, United States of America
Yumi Mitsuya, Soo-Yon Rhee, Chunlin Wang, Robert W. Shafer
Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, United States of America
Baback Gharizadeh, Mostafa Ronaghi
Genome Technology Center, Stanford University, Palo Alto, California, United States of America
Niko Beerenwinkel
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: YM SR CW BG MR RS. Analyzed the data: NE LP NB. Wrote the paper: NE LP NB.