Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins

Jason W. Locasale; Arup K. Chakraborty

doi:10.1371/journal.pcbi.1000099

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Open Access

Peer-reviewed

Research Article

Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins

Jason W. Locasale,

Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Arup K. Chakraborty

* E-mail: arupc@MIT.edu

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯

Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins

Jason W. Locasale,
Arup K. Chakraborty

Published: June 27, 2008
https://doi.org/10.1371/journal.pcbi.1000099

About the Authors

Jason W. Locasale

Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Arup K. Chakraborty

* E-mail: arupc@MIT.edu

Affiliations Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL. Performed the experiments: JL. Analyzed the data: JL. Contributed reagents/materials/analysis tools: JL. Wrote the paper: JL AC.

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Protein kinase signaling cascade
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MAPK signaling cascades
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Signal transduction
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Monte Carlo method
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Protein kinases
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Biochemical simulations
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Cell signaling
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ERK signaling cascade
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