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Research Article

Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins

  • Jason W. Locasale,

    Affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Arup K. Chakraborty mail

    arupc@MIT.edu

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: June 27, 2008
  • DOI: 10.1371/journal.pcbi.1000099

About the Authors

Jason W. Locasale, Arup K. Chakraborty
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Arup K. Chakraborty
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Arup K. Chakraborty
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: arupc@MIT.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL. Performed the experiments: JL. Analyzed the data: JL. Contributed reagents/materials/analysis tools: JL. Wrote the paper: JL AC.