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Research Article

The Ascent of the Abundant: How Mutational Networks Constrain Evolution

  • Matthew C. Cowperthwaite mail,

    mattccowp@mac.com

    Affiliation: Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • Evan P. Economo,

    Affiliation: Section for Integrative Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • William R. Harcombe,

    Affiliation: Section for Integrative Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • Eric L. Miller,

    Affiliation: Section for Integrative Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • Lauren Ancel Meyers

    Affiliations: Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Section for Integrative Biology, University of Texas at Austin, Austin, Texas, United States of America

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  • Published: July 18, 2008
  • DOI: 10.1371/journal.pcbi.1000110

About the Authors

Matthew C. Cowperthwaite, Lauren Ancel Meyers
Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
Evan P. Economo, William R. Harcombe, Eric L. Miller, Lauren Ancel Meyers
Section for Integrative Biology, University of Texas at Austin, Austin, Texas, United States of America

Corresponding Author

Email: mattccowp@mac.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC EE WH EM LM. Performed the experiments: MC. Analyzed the data: MC EE WH EM LM. Contributed reagents/materials/analysis tools: MC. Wrote the paper: MC EE LM.