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Research Article

Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions

  • Denise G. Teotico,

    Affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Monica L. Frazier,

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Feng Ding,

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Nikolay V. Dokholyan,

    Affiliations: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Brenda R. S. Temple,

    Affiliation: University of North Carolina RL Juliano Structural Bioinformatics Core Facility, Chapel Hill, North Carolina, United States of America

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  • Matthew R. Redinbo mail

    redinbo@unc.edu

    Affiliations: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: July 11, 2008
  • DOI: 10.1371/journal.pcbi.1000111

About the Authors

Denise G. Teotico, Matthew R. Redinbo
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Monica L. Frazier, Feng Ding, Nikolay V. Dokholyan, Matthew R. Redinbo
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Nikolay V. Dokholyan, Matthew R. Redinbo
The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Brenda R. S. Temple
University of North Carolina RL Juliano Structural Bioinformatics Core Facility, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: redinbo@unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DT MF BT MR. Performed the experiments: DT MF BT. Analyzed the data: DT MF FD BT. Contributed reagents/materials/analysis tools: DT MF FD ND BT. Wrote the paper: DT MF MR.