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Research Article

Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality

  • Elena Zotenko,

    Affiliation: Max-Planck Institute for Informatics, Saarbruecken, Germany

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  • Julian Mestre,

    Affiliation: Max-Planck Institute for Informatics, Saarbruecken, Germany

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  • Dianne P. O'Leary,

    Affiliations: Department of Computer Science, University of Maryland, College Park, Maryland, United States of America, Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, United States of America

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  • Teresa M. Przytycka mail

    przytyck@ncbi.nlm.nih.gov

    Affiliation: National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: August 01, 2008
  • DOI: 10.1371/journal.pcbi.1000140

About the Authors

Elena Zotenko, Julian Mestre
Max-Planck Institute for Informatics, Saarbruecken, Germany
Dianne P. O'Leary
Department of Computer Science, University of Maryland, College Park, Maryland, United States of America
Dianne P. O'Leary
Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, United States of America
Teresa M. Przytycka
National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: przytyck@ncbi.nlm.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EZ TMP. Performed the experiments: EZ. Analyzed the data: EZ DPO TMP. Wrote the paper: EZ. Contributed the algorithm for efficient computation of edge-disjoint path integrity measure: JM. Contributed to designing the experiments and writing the paper: DPO. Participated in writing the paper: TP.