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Research Article

Modeling ChIP Sequencing In Silico with Applications

  • Zhengdong D. Zhang,

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Joel Rozowsky,

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Michael Snyder,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

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  • Joseph Chang,

    Affiliation: Department of Statistics, Yale University, New Haven, Connecticut, United States of America

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  • Mark Gerstein mail

    mark.gerstein@yale.edu

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Published: August 22, 2008
  • DOI: 10.1371/journal.pcbi.1000158

About the Authors

Zhengdong D. Zhang, Joel Rozowsky, Mark Gerstein
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Michael Snyder
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, United States of America
Joseph Chang
Department of Statistics, Yale University, New Haven, Connecticut, United States of America
Mark Gerstein
Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America
Mark Gerstein
Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

Corresponding Author

Email: mark.gerstein@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZDZ JC. Performed the experiments: ZDZ. Analyzed the data: ZDZ. Contributed reagents/materials/analysis tools: JR MS. Wrote the paper: ZDZ MBG.