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Research Article

Protein Meta-Functional Signatures from Combining Sequence, Structure, Evolution, and Amino Acid Property Information

  • Kai Wang,

    Affiliations: Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Jeremy A. Horst,

    Affiliations: Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Oral Biology, University of Washington, Seattle, Washington, United States of America

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  • Gong Cheng,

    Affiliations: Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • David C. Nickle,

    Affiliation: Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Ram Samudrala mail

    ram@compbio.washington.edu

    Affiliations: Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Oral Biology, University of Washington, Seattle, Washington, United States of America

    X
  • Published: September 26, 2008
  • DOI: 10.1371/journal.pcbi.1000181

About the Authors

Kai Wang, Jeremy A. Horst, Gong Cheng, David C. Nickle, Ram Samudrala
Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Kai Wang
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Jeremy A. Horst, Ram Samudrala
Department of Oral Biology, University of Washington, Seattle, Washington, United States of America
Gong Cheng
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: ram@compbio.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS. Performed the experiments: KW. Analyzed the data: KW JAH. Contributed reagents/materials/analysis tools: GC DCN. Wrote the paper: KW.