Advertisement
Research Article

Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks

  • Marcelo Behar,

    Affiliations: Department of Physics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Program in Cellular and Molecular Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Nan Hao,

    Affiliation: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Henrik G. Dohlman,

    Affiliations: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Timothy C. Elston mail

    telston@med.unc.edu

    Affiliation: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Published: October 10, 2008
  • DOI: 10.1371/journal.pcbi.1000197

About the Authors

Marcelo Behar
Department of Physics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Marcelo Behar
Program in Cellular and Molecular Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Nan Hao, Henrik G. Dohlman, Timothy C. Elston
Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
Henrik G. Dohlman
Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: telston@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB NH HGD TCE. Performed the experiments: NH. Analyzed the data: MB NH. Wrote the paper: MB HGD TCE.