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Research Article

Genome-Scale Reconstruction and Analysis of the Pseudomonas putida KT2440 Metabolic Network Facilitates Applications in Biotechnology

  • Jacek Puchałka equal contributor,

    equal contributor Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

    Affiliation: Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

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  • Matthew A. Oberhardt equal contributor,

    equal contributor Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

    Affiliation: Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia, United States of America

    X
  • Miguel Godinho,

    Affiliation: Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

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  • Agata Bielecka,

    Affiliation: Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

    X
  • Daniela Regenhardt,

    Affiliation: Environmental Microbiology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

    X
  • Kenneth N. Timmis,

    Affiliation: Environmental Microbiology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

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  • Jason A. Papin equal contributor mail,

    equal contributor Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

    papin@virginia.edu (JAP); vds@helmholtz-hzi.de (VAPMdS)

    Affiliation: Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia, United States of America

    X
  • Vítor A. P. Martins dos Santos equal contributor mail

    equal contributor Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

    papin@virginia.edu (JAP); vds@helmholtz-hzi.de (VAPMdS)

    Affiliation: Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

    X
  • Published: October 31, 2008
  • DOI: 10.1371/journal.pcbi.1000210

About the Authors

Jacek Puchałka, Miguel Godinho, Agata Bielecka, Vítor A. P. Martins dos Santos
Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany
Matthew A. Oberhardt, Jason A. Papin
Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia, United States of America
Daniela Regenhardt, Kenneth N. Timmis
Environmental Microbiology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP MAO KNT JAP VAPMdS. Analyzed the data: JP MAO. Wrote the paper: JP MAO JAP VAPMdS. Performed the computational experiments: JP. Developed the computational platform: MG. Characterized the mutants and carried out wet lab experiments: AB. Produced the mutants: DR. Contributed to data interpretation: KNT.