About the Authors

Jacek Puchałka

Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

Affiliation Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Matthew A. Oberhardt

Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

Affiliation Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia, United States of America

Miguel Godinho

Affiliation Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Agata Bielecka

Affiliation Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Daniela Regenhardt

Affiliation Environmental Microbiology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Kenneth N. Timmis

Affiliation Environmental Microbiology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Jason A. Papin

Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

papin@virginia.edu (JAP); vds@helmholtz-hzi.de (VAPMdS)

Affiliation Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, Virginia, United States of America

Vítor A. P. Martins dos Santos

Contributed equally to this work with: Jacek Puchałka, Matthew A. Oberhardt, Jason A. Papin, Vítor A. P. Martins dos Santos

papin@virginia.edu (JAP); vds@helmholtz-hzi.de (VAPMdS)

Affiliation Synthetic and Systems Biology Group, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP MAO KNT JAP VAPMdS. Analyzed the data: JP MAO. Wrote the paper: JP MAO JAP VAPMdS. Performed the computational experiments: JP. Developed the computational platform: MG. Characterized the mutants and carried out wet lab experiments: AB. Produced the mutants: DR. Contributed to data interpretation: KNT.