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Research Article

Transmembrane Topology and Signal Peptide Prediction Using Dynamic Bayesian Networks

  • Sheila M. Reynolds,

    Affiliation: Department of Electrical Engineering, University of Washington, Seattle, Washington, United States of America

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  • Lukas Käll,

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Michael E. Riffle,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Jeff A. Bilmes,

    Affiliations: Department of Electrical Engineering, University of Washington, Seattle, Washington, United States of America, Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America

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  • William Stafford Noble mail

    noble@gs.washington.edu

    Affiliations: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America

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  • Published: November 07, 2008
  • DOI: 10.1371/journal.pcbi.1000213

About the Authors

Sheila M. Reynolds, Jeff A. Bilmes
Department of Electrical Engineering, University of Washington, Seattle, Washington, United States of America
Lukas Käll, William Stafford Noble
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Michael E. Riffle
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
Jeff A. Bilmes, William Stafford Noble
Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: noble@gs.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SMR LK JAB WSN. Performed the experiments: SMR. Analyzed the data: SMR MER. Contributed reagents/materials/analysis tools: SMR MER JAB. Wrote the paper: SMR LK JAB WSN. Imported predictions into database and developed web interface: MR.