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Research Article

Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes

  • Osnat Penn equal contributor,

    equal contributor Contributed equally to this work with: Osnat Penn, Adi Stern

    Affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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  • Adi Stern equal contributor,

    equal contributor Contributed equally to this work with: Osnat Penn, Adi Stern

    Affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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  • Nimrod D. Rubinstein,

    Affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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  • Julien Dutheil,

    Affiliation: BiRC—Bioinformatics Research Center, University of Aarhus, Århus, Denmark

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  • Eran Bacharach,

    Affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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  • Nicolas Galtier,

    Affiliation: Institut des Sciences de l'Evolution—CC64, Centre National de la Recherche Scientifique—Université Montpellier 2, Montpelier, France

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  • Tal Pupko mail

    talp@post.tau.ac.il

    Affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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  • Published: November 07, 2008
  • DOI: 10.1371/journal.pcbi.1000214

About the Authors

Osnat Penn, Adi Stern, Nimrod D. Rubinstein, Eran Bacharach, Tal Pupko
Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
Julien Dutheil
BiRC—Bioinformatics Research Center, University of Aarhus, Århus, Denmark
Nicolas Galtier
Institut des Sciences de l'Evolution—CC64, Centre National de la Recherche Scientifique—Université Montpellier 2, Montpelier, France

Corresponding Author

Email: talp@post.tau.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OP AS JD NG TP. Performed the experiments: OP AS. Analyzed the data: OP AS NDR. Wrote the paper: OP AS NDR TP. Provided expert advice: JD EB NG.