About the Authors
- Sonia M. Leach
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Contributed equally to this work with: Sonia M. Leach, Hannah Tipney
Current address: Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium.
Affiliation Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, United States of America
- Hannah Tipney
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Contributed equally to this work with: Sonia M. Leach, Hannah Tipney
Affiliation Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, United States of America
- Weiguo Feng
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Affiliation Department of Craniofacial Biology, University of Colorado at Denver, Denver, Colorado, United States of America
- William A. Baumgartner Jr.
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Affiliation Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, United States of America
- Priyanka Kasliwal
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Affiliation Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, United States of America
- Ronald P. Schuyler
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Affiliation Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, United States of America
- Trevor Williams
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Affiliation Department of Craniofacial Biology, University of Colorado at Denver, Denver, Colorado, United States of America
- Richard A. Spritz
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Affiliation Human Medical Genetics Program, University of Colorado at Denver, Denver, Colorado, United States of America
- Lawrence Hunter
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* E-mail: Larry.Hunter@ucdenver.edu
Affiliation Center for Computational Pharmacology, University of Colorado at Denver, Denver, Colorado, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: SML LH. Performed the experiments: SML WF. Analyzed the data: SML HT TW RAS. Contributed reagents/materials/analysis tools: SML WAB PK RPS. Wrote the paper: SML HT TW RAS LH. Designed and implemented the initial reading and reasoning components of the system, created the networks and contributed to the manuscript: SML. Contributed to the design of the system, used the system to interpret the craniofacial data, identified and developed the biological hypothesis, and contributed to the manuscript: HT. Did the mouse dissections and in situ staining to validate the system's results: WF. Designed and supervised a software reimplementation to facilitate broader distribution of the system: WAB. Implemented the reading and reasoning components to facilitate dynamic updates and further development: PK. Implemented aspects of the reporting component that facilitated direct access to the underlying knowledge and its provenance: RPS. Advised on and evaluated the significance of the developmental biology and contributed to the manuscript: TW. Advised on and evaluated the significance of the genetics and contributed to the manuscript: RAS. Conceived of the overall system, supervised all aspects of its construction, and wrote the initial and final drafts of the manuscript: LH.