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Research Article

Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking

  • Yuki Tsukada,

    Affiliations: Laboratory for Systems Biology, Graduate School of Information Science, Nara Institute of Science and Technology, Nara, Japan, Institute for Bioinformatics Research and Development, Japan Science and Technology Agency, Tokyo, Japan

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  • Kazuhiro Aoki,

    Affiliation: Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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  • Takeshi Nakamura,

    Affiliation: Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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  • Yuichi Sakumura,

    Affiliations: Laboratory for Systems Biology, Graduate School of Information Science, Nara Institute of Science and Technology, Nara, Japan, Institute for Bioinformatics Research and Development, Japan Science and Technology Agency, Tokyo, Japan

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  • Michiyuki Matsuda,

    Affiliation: Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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  • Shin Ishii mail

    ishii@i.kyoto-u.ac.jp

    Affiliations: Laboratory for Systems Biology, Graduate School of Information Science, Nara Institute of Science and Technology, Nara, Japan, Institute for Bioinformatics Research and Development, Japan Science and Technology Agency, Tokyo, Japan, Integrated Systems Biology Laboratory, Department of Systems Science, Graduate School of Informatics, Kyoto University, Kyoto, Japan

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  • Published: November 14, 2008
  • DOI: 10.1371/journal.pcbi.1000223

About the Authors

Yuki Tsukada, Yuichi Sakumura, Shin Ishii
Laboratory for Systems Biology, Graduate School of Information Science, Nara Institute of Science and Technology, Nara, Japan
Yuki Tsukada, Yuichi Sakumura, Shin Ishii
Institute for Bioinformatics Research and Development, Japan Science and Technology Agency, Tokyo, Japan
Kazuhiro Aoki, Takeshi Nakamura, Michiyuki Matsuda
Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
Shin Ishii
Integrated Systems Biology Laboratory, Department of Systems Science, Graduate School of Informatics, Kyoto University, Kyoto, Japan

Corresponding Author

Email: ishii@i.kyoto-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YT KA TN YS. Performed the experiments: KA MM. Analyzed the data: YT. Contributed reagents/materials/analysis tools: YT. Wrote the paper: YT KA TN YS MM SI.