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Research Article

Spontaneous Reaction Silencing in Metabolic Optimization

  • Takashi Nishikawa,

    Affiliations: Division of Mathematics and Computer Science, Clarkson University, Potsdam, New York, United States of America, Department of Physics and Astronomy and Northwestern Institute on Complex Systems, Northwestern University, Evanston, Illinois, United States of America

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  • Natali Gulbahce,

    Affiliations: Department of Physics and Center for Complex Network Research, Northeastern University, Boston, Massachusetts, United States of America, Center for Cancer Systems Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Adilson E. Motter mail

    motter@northwestern.edu

    Affiliation: Department of Physics and Astronomy and Northwestern Institute on Complex Systems, Northwestern University, Evanston, Illinois, United States of America

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  • Published: December 05, 2008
  • DOI: 10.1371/journal.pcbi.1000236

About the Authors

Takashi Nishikawa
Division of Mathematics and Computer Science, Clarkson University, Potsdam, New York, United States of America
Takashi Nishikawa, Adilson E. Motter
Department of Physics and Astronomy and Northwestern Institute on Complex Systems, Northwestern University, Evanston, Illinois, United States of America
Natali Gulbahce
Department of Physics and Center for Complex Network Research, Northeastern University, Boston, Massachusetts, United States of America
Natali Gulbahce
Center for Cancer Systems Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Corresponding Author

Email: motter@northwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AEM. Performed the experiments: NG. Analyzed the data: TN NG AEM. Contributed reagents/materials/analysis tools: TN NG. Wrote the paper: TN AEM.