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Research Article

Partial Order Optimum Likelihood (POOL): Maximum Likelihood Prediction of Protein Active Site Residues Using 3D Structure and Sequence Properties

  • Wenxu Tong,

    Affiliations: College of Computer and Information Science, Northeastern University, Boston, Massachusetts, United States of America, Institute for Complex Scientific Software, Northeastern University, Boston, Massachusetts, United States of America

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  • Ying Wei,

    Affiliations: Institute for Complex Scientific Software, Northeastern University, Boston, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

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  • Leonel F. Murga,

    Affiliations: Institute for Complex Scientific Software, Northeastern University, Boston, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

    X
  • Mary Jo Ondrechen mail,

    M.Ondrechen@neu.edu (MO); rjw@ccs.neu.edu (RJW)

    Affiliations: Institute for Complex Scientific Software, Northeastern University, Boston, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

    X
  • Ronald J. Williams mail

    M.Ondrechen@neu.edu (MO); rjw@ccs.neu.edu (RJW)

    Affiliations: College of Computer and Information Science, Northeastern University, Boston, Massachusetts, United States of America, Institute for Complex Scientific Software, Northeastern University, Boston, Massachusetts, United States of America

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  • Published: January 16, 2009
  • DOI: 10.1371/journal.pcbi.1000266

About the Authors

Wenxu Tong, Ronald J. Williams
College of Computer and Information Science, Northeastern University, Boston, Massachusetts, United States of America
Wenxu Tong, Ying Wei, Leonel F. Murga, Mary Jo Ondrechen, Ronald J. Williams
Institute for Complex Scientific Software, Northeastern University, Boston, Massachusetts, United States of America
Ying Wei, Leonel F. Murga, Mary Jo Ondrechen
Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WT MJO RJW. Performed the experiments: WT YW LFM. Analyzed the data: WT YW LFM MJO RJW. Contributed reagents/materials/analysis tools: MJO RJW. Wrote the paper: WT MJO RJW.