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Research Article

Detection of Alpha-Rod Protein Repeats Using a Neural Network and Application to Huntingtin

  • Gareth A. Palidwor,

    Affiliation: Ottawa Health Research Institute, Ottawa, Ontario, Canada

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  • Sergey Shcherbinin,

    Affiliation: Medical Imaging Research Group, The University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada

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  • Matthew R. Huska,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Tamas Rasko,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Ulrich Stelzl,

    Affiliation: Otto-Warburg Laboratory, Max Planck Institute for Molecular Genetics, Berlin, Germany

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  • Anup Arumughan,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Raphaele Foulle,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Pablo Porras,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Luis Sanchez-Pulido,

    Affiliation: Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

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  • Erich E. Wanker,

    Affiliation: Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Miguel A. Andrade-Navarro mail

    Miguel.andrade@mdc-berlin.de

    Affiliations: Ottawa Health Research Institute, Ottawa, Ontario, Canada, Max-Delbrück Center for Molecular Medicine, Berlin, Germany

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  • Published: March 13, 2009
  • DOI: 10.1371/journal.pcbi.1000304

About the Authors

Gareth A. Palidwor, Miguel A. Andrade-Navarro
Ottawa Health Research Institute, Ottawa, Ontario, Canada
Sergey Shcherbinin
Medical Imaging Research Group, The University of British Columbia, Vancouver General Hospital, Vancouver, British Columbia, Canada
Matthew R. Huska, Tamas Rasko, Anup Arumughan, Raphaele Foulle, Pablo Porras, Erich E. Wanker, Miguel A. Andrade-Navarro
Max-Delbrück Center for Molecular Medicine, Berlin, Germany
Ulrich Stelzl
Otto-Warburg Laboratory, Max Planck Institute for Molecular Genetics, Berlin, Germany
Luis Sanchez-Pulido
Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: Miguel.andrade@mdc-berlin.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EEW MAAN. Performed the experiments: GAP TR US AA RF PP. Analyzed the data: GAP TR US LSP. Contributed reagents/materials/analysis tools: GAP SS MRH. Wrote the paper: MAAN.