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Research Article

Mechanical Network in Titin Immunoglobulin from Force Distribution Analysis

  • Wolfram Stacklies equal contributor,

    equal contributor Contributed equally to this work with: Wolfram Stacklies, M. Cristina Vega

    Affiliation: CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai, People's Republic of China

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  • M. Cristina Vega equal contributor,

    equal contributor Contributed equally to this work with: Wolfram Stacklies, M. Cristina Vega

    Affiliation: Institut de Biologia Molecular de Barcelona (IBMB-CSIC) and Institute for Research in Biomedicine (IRB), Barcelona, Spain

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  • Matthias Wilmanns,

    Affiliation: EMBL-Hamburg Unit, Hamburg, Gemany

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  • Frauke Gräter mail

    frauke@picb.ac.cn

    Affiliations: CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai, People's Republic of China, Bioquant BQ0031, Universität Heidelberg, Heidelberg, Germany, Max-Planck Institute for Metals Research, Stuttgart, Germany

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  • Published: March 13, 2009
  • DOI: 10.1371/journal.pcbi.1000306

About the Authors

Wolfram Stacklies, Frauke Gräter
CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai, People's Republic of China
M. Cristina Vega
Institut de Biologia Molecular de Barcelona (IBMB-CSIC) and Institute for Research in Biomedicine (IRB), Barcelona, Spain
Matthias Wilmanns
EMBL-Hamburg Unit, Hamburg, Gemany
Frauke Gräter
Bioquant BQ0031, Universität Heidelberg, Heidelberg, Germany
Frauke Gräter
Max-Planck Institute for Metals Research, Stuttgart, Germany

Corresponding Author

Email: frauke@picb.ac.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WS MCV MW FG. Performed the experiments: WS MCV. Analyzed the data: WS MCV FG. Contributed reagents/materials/analysis tools: WS MCV. Wrote the paper: WS MCV FG. Force distribution and evolutionary coupling: WS. Protein production, crystallization, and structure determination: MCV.