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Research Article

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

  • Junghyo Jo,

    Affiliation: Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

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  • Oksana Gavrilova,

    Affiliation: Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

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  • Stephanie Pack,

    Affiliation: Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

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  • William Jou,

    Affiliation: Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

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  • Shawn Mullen,

    Affiliation: GPP/OITE/OIR/OD, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Anne E. Sumner,

    Affiliation: Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

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  • Samuel W. Cushman,

    Affiliation: Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

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  • Vipul Periwal mail

    vipulp@mail.nih.gov

    Affiliation: Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

    X
  • Published: March 27, 2009
  • DOI: 10.1371/journal.pcbi.1000324

About the Authors

Junghyo Jo, Vipul Periwal
Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America
Oksana Gavrilova, Stephanie Pack, William Jou
Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America
Shawn Mullen
GPP/OITE/OIR/OD, National Institutes of Health, Bethesda, Maryland, United States of America
Anne E. Sumner
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America
Samuel W. Cushman
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, United States of America

Corresponding Author

Email: vipulp@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JJ OG AES SWC VP. Performed the experiments: OG SP WJ SM. Analyzed the data: JJ OG VP. Wrote the paper: JJ OG SWC VP.