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Research Article

Ras Conformational Switching: Simulating Nucleotide-Dependent Conformational Transitions with Accelerated Molecular Dynamics

  • Barry J. Grant equal contributor mail,

    equal contributor Contributed equally to this work with: Barry J. Grant, Alemayehu A. Gorfe

    bgrant@mccammon.ucsd.edu (BJG); abebe@mccammon.ucsd.edu (AAG)

    Affiliation: Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America

    X
  • Alemayehu A. Gorfe equal contributor mail,

    equal contributor Contributed equally to this work with: Barry J. Grant, Alemayehu A. Gorfe

    bgrant@mccammon.ucsd.edu (BJG); abebe@mccammon.ucsd.edu (AAG)

    Affiliation: Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America

    X
  • J. Andrew McCammon

    Affiliations: Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

    X
  • Published: March 20, 2009
  • DOI: 10.1371/journal.pcbi.1000325

About the Authors

Barry J. Grant, Alemayehu A. Gorfe, J. Andrew McCammon
Department of Chemistry and Biochemistry and Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BJG AAG JAM. Performed the experiments: BJG AAG. Analyzed the data: BJG AAG. Contributed reagents/materials/analysis tools: BJG AAG JAM. Wrote the paper: BJG AAG JAM.