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Research Article

Information Flow Analysis of Interactome Networks

  • Patrycja Vasilyev Missiuro,

    Affiliations: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Kesheng Liu,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Lihua Zou,

    Affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Brian C. Ross,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Guoyan Zhao,

    Affiliation: Department of Genetics, Washington University, St. Louis, Missouri, United States of America

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  • Jun S. Liu,

    Affiliation: Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

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  • Hui Ge mail

    hge@wi.mit.edu

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Published: April 10, 2009
  • DOI: 10.1371/journal.pcbi.1000350

About the Authors

Patrycja Vasilyev Missiuro, Kesheng Liu, Brian C. Ross, Hui Ge
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Patrycja Vasilyev Missiuro
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Lihua Zou
Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Guoyan Zhao
Department of Genetics, Washington University, St. Louis, Missouri, United States of America
Jun S. Liu
Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: hge@wi.mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PVM LZ BCR JSL HG. Performed the experiments: KL. Analyzed the data: PVM GZ HG. Contributed reagents/materials/analysis tools: PVM. Wrote the paper: PVM HG. Responsible for all computational work, designed and implemented an independent version of algorithm that is introduced in the paper: PVM. Responsible for all experimental work that is presented in the paper: KL. Originally discussed the idea, designed another independent version of the algorithm (not used in the paper): LZ BCR. Provided computational analysis on muscle-specific motif modules that is used in the paper: GZ.