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Research Article

A Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its Family

  • Gregory D. Friedland,

    Affiliations: Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America

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  • Nils-Alexander Lakomek,

    Affiliation: Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany

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  • Christian Griesinger,

    Affiliation: Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany

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  • Jens Meiler mail,

    jens.meiler@vanderbilt.edu (JM); kortemme@cgl.ucsf.edu (TK)

    Affiliation: Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Tanja Kortemme mail

    jens.meiler@vanderbilt.edu (JM); kortemme@cgl.ucsf.edu (TK)

    Affiliations: Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America

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  • Published: May 29, 2009
  • DOI: 10.1371/journal.pcbi.1000393

About the Authors

Gregory D. Friedland, Tanja Kortemme
Graduate Group in Biophysics, University of California San Francisco, San Francisco, California, United States of America
Gregory D. Friedland, Tanja Kortemme
Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America
Gregory D. Friedland, Tanja Kortemme
California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America
Nils-Alexander Lakomek, Christian Griesinger
Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany
Jens Meiler
Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GDF JM TK. Performed the experiments: GDF. Analyzed the data: GDF JM TK. Contributed reagents/materials/analysis tools: NAL CG. Wrote the paper: GDF TK.