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Research Article

The Dynamics of T-Cell Receptor Repertoire Diversity Following Thymus Transplantation for DiGeorge Anomaly

  • Stanca M. Ciupe,

    Affiliation: Center for Computational Immunology, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Blythe H. Devlin,

    Affiliation: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • M. Louise Markert,

    Affiliations: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Thomas B. Kepler mail

    kepler@duke.edu

    Affiliations: Center for Computational Immunology, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.pcbi.1000396

About the Authors

Stanca M. Ciupe, Thomas B. Kepler
Center for Computational Immunology, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America
Blythe H. Devlin, M. Louise Markert
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America
M. Louise Markert, Thomas B. Kepler
Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Author

Email: kepler@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Wrote the paper: SMC BHD MLM TBK. Conceived the study: MLM TBK. Developed mathematical components: SMC TBK. Interpreted results: SMC BHD MLM TBK. Developed empirical components: BHD MLM.