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Research Article

Directed Mammalian Gene Regulatory Networks Using Expression and Comparative Genomic Hybridization Microarray Data from Radiation Hybrids

  • Sangtae Ahn,

    Affiliation: Signal and Image Processing Institute, University of Southern California, Los Angeles, California, United States of America

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  • Richard T. Wang,

    Affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Christopher C. Park,

    Affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Andy Lin,

    Affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Richard M. Leahy,

    Affiliation: Signal and Image Processing Institute, University of Southern California, Los Angeles, California, United States of America

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  • Kenneth Lange,

    Affiliation: Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Desmond J. Smith mail

    DSmith@mednet.ucla.edu

    Affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.pcbi.1000407

About the Authors

Sangtae Ahn, Richard M. Leahy
Signal and Image Processing Institute, University of Southern California, Los Angeles, California, United States of America
Richard T. Wang, Christopher C. Park, Andy Lin, Desmond J. Smith
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
Kenneth Lange
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: DSmith@mednet.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJS. Wrote the paper: SA DJS. Developed the methods: SA RML KL DJS. Implemented the methods: SA. Processed various data sets: RTW CCP AL.