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Research Article

Integrating Sequencing Technologies in Personal Genomics: Optimal Low Cost Reconstruction of Structural Variants

  • Jiang Du,

    Affiliation: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America

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  • Robert D. Bjornson,

    Affiliations: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America, Keck Biotechnology Resource Laboratory, Yale University, New Haven, Connecticut, United States of America

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  • Zhengdong D. Zhang,

    Affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Yong Kong,

    Affiliation: Keck Biotechnology Resource Laboratory, Yale University, New Haven, Connecticut, United States of America

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  • Michael Snyder,

    Affiliations: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

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  • Mark B. Gerstein mail

    Mark.Gerstein@yale.edu

    Affiliations: Department of Computer Science, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

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  • Published: July 10, 2009
  • DOI: 10.1371/journal.pcbi.1000432

About the Authors

Jiang Du, Robert D. Bjornson, Mark B. Gerstein
Department of Computer Science, Yale University, New Haven, Connecticut, United States of America
Robert D. Bjornson, Yong Kong
Keck Biotechnology Resource Laboratory, Yale University, New Haven, Connecticut, United States of America
Zhengdong D. Zhang, Michael Snyder, Mark B. Gerstein
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Michael Snyder
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America
Mark B. Gerstein
Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Corresponding Author

Email: Mark.Gerstein@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JD RDB ZDZ MBG. Performed the experiments: JD. Analyzed the data: JD RDB ZDZ YK MS MBG. Contributed reagents/materials/analysis tools: JD RDB. Wrote the paper: JD MBG.