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Research Article

Cooperativity Dominates the Genomic Organization of p53-Response Elements: A Mechanistic View

  • Yongping Pan,

    Affiliation: Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, United States of America

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  • Ruth Nussinov mail

    ruthnu@helix.nih.gov

    Affiliations: Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, United States of America, Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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  • Published: July 24, 2009
  • DOI: 10.1371/journal.pcbi.1000448

About the Authors

Yongping Pan, Ruth Nussinov
Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, United States of America
Ruth Nussinov
Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Corresponding Author

Email: ruthnu@helix.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YP RN. Performed the experiments: YP. Analyzed the data: YP. Contributed reagents/materials/analysis tools: YP. Wrote the paper: YP RN.