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Research Article

Building Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts

  • Jiao Li,

    Affiliations: State Key Laboratory of Intelligent Technology and Systems, Tsinghua National Laboratory for Information Science and Technology, Department of Computer Science and Technology, Tsinghua University, Beijing, China, Department of Computer & Information Science, School of Science, Purdue University, Indianapolis, Indiana, United States of America

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  • Xiaoyan Zhu,

    Affiliation: State Key Laboratory of Intelligent Technology and Systems, Tsinghua National Laboratory for Information Science and Technology, Department of Computer Science and Technology, Tsinghua University, Beijing, China

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  • Jake Yue Chen mail

    jakechen@iupui.edu

    Affiliations: School of Informatics, Indiana University, Indianapolis, Indiana, United States of America, Department of Computer & Information Science, School of Science, Purdue University, Indianapolis, Indiana, United States of America, Indiana Center for Systems Biology and Personalized Medicine, Indiana University–Purdue University, Indianapolis, Indiana, United States of America

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  • Published: July 31, 2009
  • DOI: 10.1371/journal.pcbi.1000450

About the Authors

Jiao Li, Xiaoyan Zhu
State Key Laboratory of Intelligent Technology and Systems, Tsinghua National Laboratory for Information Science and Technology, Department of Computer Science and Technology, Tsinghua University, Beijing, China
Jake Yue Chen
School of Informatics, Indiana University, Indianapolis, Indiana, United States of America
Jiao Li, Jake Yue Chen
Department of Computer & Information Science, School of Science, Purdue University, Indianapolis, Indiana, United States of America
Jake Yue Chen
Indiana Center for Systems Biology and Personalized Medicine, Indiana University–Purdue University, Indianapolis, Indiana, United States of America

Corresponding Author

Email: jakechen@iupui.edu

Competing Interests

Jake Chen discloses that he is also the founder of MedeoLinx, LLC, an Indianapolis startup biotech company to provide novel drug discovery products and services based on translational systems biology.

Author Contributions

Conceived and designed the experiments: JL JYC. Performed the experiments: JL. Analyzed the data: JL JYC. Contributed reagents/materials/analysis tools: JL JYC. Wrote the paper: JL JYC. Provided support throughout the research process: XZ.