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Research Article

Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations

  • Anshuman Dixit,

    Affiliation: Graduate Program in Bioinformatics and Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America

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  • Gennady M. Verkhivker mail

    verk@ku.edu

    Affiliations: Graduate Program in Bioinformatics and Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America, Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America, Department of Pharmacology, University of California at San Diego, La Jolla, California, United States of America

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  • Published: August 28, 2009
  • DOI: 10.1371/journal.pcbi.1000487

About the Authors

Anshuman Dixit, Gennady M. Verkhivker
Graduate Program in Bioinformatics and Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, United States of America
Gennady M. Verkhivker
Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, United States of America
Gennady M. Verkhivker
Department of Pharmacology, University of California at San Diego, La Jolla, California, United States of America

Corresponding Author

Email: verk@ku.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GMV. Performed the experiments: AD GMV. Analyzed the data: AD GMV. Wrote the paper: GMV.