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Research Article

An Atlas of the Thioredoxin Fold Class Reveals the Complexity of Function-Enabling Adaptations

  • Holly J. Atkinson,

    Affiliations: Graduate Program in Biological and Medical Informatics, University of California, San Francisco, California, United States of America, Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America

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  • Patricia C. Babbitt mail

    babbitt@cgl.ucsf.edu

    Affiliations: Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Published: October 23, 2009
  • DOI: 10.1371/journal.pcbi.1000541

About the Authors

Holly J. Atkinson
Graduate Program in Biological and Medical Informatics, University of California, San Francisco, California, United States of America
Holly J. Atkinson, Patricia C. Babbitt
Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America
Patricia C. Babbitt
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America
Patricia C. Babbitt
Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

Corresponding Author

Email: babbitt@cgl.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HJA PCB. Performed the experiments: HJA. Analyzed the data: HJA. Wrote the paper: HJA PCB.