Advertisement
Research Article

Structure of Protein Interaction Networks and Their Implications on Drug Design

  • Takeshi Hase equal contributor,

    equal contributor Contributed equally to this work with: Takeshi Hase, Hiroshi Tanaka

    Affiliation: Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

    X
  • Hiroshi Tanaka equal contributor mail,

    equal contributor Contributed equally to this work with: Takeshi Hase, Hiroshi Tanaka

    kitano@sbi.jp (HK); tanaka@cim.tmd.ac.jp (HT)

    Affiliation: Department of Bioinformatics, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

    X
  • Yasuhiro Suzuki,

    Affiliation: Department of Complex Systems Science, Graduate School of Information Science, Nagoya University, Nagoya, Aichi, Japan

    X
  • So Nakagawa,

    Affiliation: Center for Information Biology and DNA Databank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan

    X
  • Hiroaki Kitano mail

    kitano@sbi.jp (HK); tanaka@cim.tmd.ac.jp (HT)

    Affiliations: Sony Computer Science Laboratories, Shinagawa, Tokyo, Japan, The Systems Biology Institute, Minato, Tokyo, Japan, Okinawa Institute of Science and Technology, Kunigami, Okinawa, Japan

    X
  • Published: October 30, 2009
  • DOI: 10.1371/journal.pcbi.1000550

About the Authors

Takeshi Hase
Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
Hiroshi Tanaka
Department of Bioinformatics, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
Yasuhiro Suzuki
Department of Complex Systems Science, Graduate School of Information Science, Nagoya University, Nagoya, Aichi, Japan
So Nakagawa
Center for Information Biology and DNA Databank of Japan, National Institute of Genetics, Mishima, Shizuoka, Japan
Hiroaki Kitano
Sony Computer Science Laboratories, Shinagawa, Tokyo, Japan
Hiroaki Kitano
The Systems Biology Institute, Minato, Tokyo, Japan
Hiroaki Kitano
Okinawa Institute of Science and Technology, Kunigami, Okinawa, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TH HT YS SN HK. Performed the experiments: TH YS SN. Analyzed the data: TH HT YS SN. Wrote the paper: TH HK.