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Research Article

Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors

  • Nathan Salomonis,

    Affiliations: Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America, Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, California, United States of America

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  • Brandon Nelson,

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Karen Vranizan,

    Affiliation: Functional Genomics Laboratory, University of California, Berkeley, Berkeley, California, United States of America

    † Deceased.

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  • Alexander R. Pico,

    Affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America

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  • Kristina Hanspers,

    Affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America

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  • Allan Kuchinsky,

    Affiliation: Agilent Technologies, Santa Clara, California, United States of America

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  • Linda Ta,

    Affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America

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  • Mark Mercola,

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Bruce R. Conklin mail

    bconklin@gladstone.ucsf.edu

    Affiliations: Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America, Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: November 06, 2009
  • DOI: 10.1371/journal.pcbi.1000553

About the Authors

Nathan Salomonis, Alexander R. Pico, Kristina Hanspers, Linda Ta, Bruce R. Conklin
Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America
Nathan Salomonis, Bruce R. Conklin
Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, California, United States of America
Brandon Nelson, Mark Mercola
Burnham Institute for Medical Research, La Jolla, California, United States of America
Karen Vranizan
Functional Genomics Laboratory, University of California, Berkeley, Berkeley, California, United States of America
Allan Kuchinsky
Agilent Technologies, Santa Clara, California, United States of America

Corresponding Author

Email: bconklin@gladstone.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NS MM BRC. Performed the experiments: NS BN LT. Analyzed the data: NS KV. Contributed reagents/materials/analysis tools: NS BN ARP KH AK BRC. Wrote the paper: NS. Was the lead investigator: MM.