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Research Article

Exon Array Analysis of Head and Neck Cancers Identifies a Hypoxia Related Splice Variant of LAMA3 Associated with a Poor Prognosis

  • Carla S. Moller-Levet equal contributor mail,

    equal contributor Contributed equally to this work with: Carla S. Moller-Levet, Guy N. J. Betts

    cmoller@picr.man.ac.uk

    Affiliations: Applied Computational Biology and Bioinformatics Group, Cancer Research UK Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital, Manchester, United Kingdom, Translational Radiobiology Group, School of Cancer and Imaging Sciences, The University of Manchester, Christie Hospital, Manchester, United Kingdom

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  • Guy N. J. Betts equal contributor,

    equal contributor Contributed equally to this work with: Carla S. Moller-Levet, Guy N. J. Betts

    Affiliation: Translational Radiobiology Group, School of Cancer and Imaging Sciences, The University of Manchester, Christie Hospital, Manchester, United Kingdom

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  • Adrian L. Harris,

    Affiliation: Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom

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  • Jarrod J. Homer,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, The University of Manchester Academic Health Science Centre, Manchester Royal Infirmary, Manchester, United Kingdom

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  • Catharine M. L. West,

    Affiliation: Translational Radiobiology Group, School of Cancer and Imaging Sciences, The University of Manchester, Christie Hospital, Manchester, United Kingdom

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  • Crispin J. Miller

    Affiliation: Applied Computational Biology and Bioinformatics Group, Cancer Research UK Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital, Manchester, United Kingdom

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  • Published: November 20, 2009
  • DOI: 10.1371/journal.pcbi.1000571

About the Authors

Carla S. Moller-Levet, Crispin J. Miller
Applied Computational Biology and Bioinformatics Group, Cancer Research UK Paterson Institute for Cancer Research, The University of Manchester, Christie Hospital, Manchester, United Kingdom
Carla S. Moller-Levet, Guy N. J. Betts, Catharine M. L. West
Translational Radiobiology Group, School of Cancer and Imaging Sciences, The University of Manchester, Christie Hospital, Manchester, United Kingdom
Adrian L. Harris
Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Jarrod J. Homer
Department of Otolaryngology-Head and Neck Surgery, The University of Manchester Academic Health Science Centre, Manchester Royal Infirmary, Manchester, United Kingdom

Corresponding Author

Email: cmoller@picr.man.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ALH CMLW CJM. Performed the experiments: GNJB. Analyzed the data: CSML. Contributed reagents/materials/analysis tools: JJH. Wrote the paper: CSML GNJB. Devised the bioinformatics approach and carried out the exon array analysis: CSML. Organized the sample collection and preparation for exon array analysis; carried out the laboratory validation assays: GNJB. Involved in the collection of samples: JJH. Edited the paper: CMLW CJM.