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Research Article

ON/OFF and Beyond - A Boolean Model of Apoptosis

  • Rebekka Schlatter mail,

    rebekka.schlatter@isys.uni-stuttgart.de

    Affiliation: Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany

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  • Kathrin Schmich,

    Affiliation: Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany

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  • Ima Avalos Vizcarra,

    Affiliations: Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland

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  • Peter Scheurich,

    Affiliation: Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany

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  • Thomas Sauter,

    Affiliation: Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg

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  • Christoph Borner,

    Affiliation: Institute of Molecular Medicine and Cell Research, Centre of Biochemistry and Molecular Research (ZBMZ), Albert Ludwigs University Freiburg, Freiburg, Germany

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  • Michael Ederer,

    Affiliations: Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany, Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

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  • Irmgard Merfort,

    Affiliation: Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany

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  • Oliver Sawodny

    Affiliation: Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany

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  • Published: December 11, 2009
  • DOI: 10.1371/journal.pcbi.1000595

About the Authors

Rebekka Schlatter, Ima Avalos Vizcarra, Michael Ederer, Oliver Sawodny
Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany
Kathrin Schmich, Irmgard Merfort
Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany
Ima Avalos Vizcarra
Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
Peter Scheurich
Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany
Thomas Sauter
Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg
Christoph Borner
Institute of Molecular Medicine and Cell Research, Centre of Biochemistry and Molecular Research (ZBMZ), Albert Ludwigs University Freiburg, Freiburg, Germany
Michael Ederer
Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany

Corresponding Author

Email: rebekka.schlatter@isys.uni-stuttgart.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS KS. Performed the experiments: KS. Analyzed the data: RS. Contributed reagents/materials/analysis tools: CB. Wrote the paper: RS KS TS CB ME IM OS. Built the mathematical model: RS IAV. Supported this work with biological expertise: PS TS CB IM. Supported this work with modeling expertise: TS ME OS.