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Research Article

Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

  • Matthew J. Paszek,

    Affiliations: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America

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  • David Boettiger,

    Affiliations: Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Valerie M. Weaver,

    Affiliations: Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America, Department of Anatomy, University of California, San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, Institute for Regenerative Medicine and UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America

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  • Daniel A. Hammer mail

    hammer@seas.upenn.edu

    Affiliations: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: December 11, 2009
  • DOI: 10.1371/journal.pcbi.1000604

About the Authors

Matthew J. Paszek, Daniel A. Hammer
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Daniel A. Hammer
Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Matthew J. Paszek, David Boettiger, Daniel A. Hammer
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
David Boettiger
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
David Boettiger
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Matthew J. Paszek, Valerie M. Weaver
Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California, United States of America
Valerie M. Weaver
Department of Anatomy, University of California, San Francisco, San Francisco, California, United States of America
Valerie M. Weaver
Department of Bioengineering and Therapeutic Sciences, Institute for Regenerative Medicine and UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: hammer@seas.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DAH. Performed the experiments: MJP. Analyzed the data: DB VMW. Wrote the paper: MJP DB VMW. Supervised the work: DAH. Helped write the paper: DAH. Assisted with analysis: DAH.