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Research Article

Design Principles for Ligand-Sensing, Conformation-Switching Ribozymes

  • Xi Chen,

    Affiliation: Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Andrew D. Ellington mail

    andy.ellington@mail.utexas.edu

    Affiliation: Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Published: December 24, 2009
  • DOI: 10.1371/journal.pcbi.1000620

About the Authors

Xi Chen, Andrew D. Ellington
Department of Chemistry and Biochemistry, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, Texas, United States of America

Corresponding Author

Email: andy.ellington@mail.utexas.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Outlined the aims and methods of the study, built the mathematical model, performed the analyses, and drafted the manuscript: XC. Suggested some of the data analyses and comparisons and critically revised the manuscript: ADE.