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Research Article

Tradeoff Between Stability and Multispecificity in the Design of Promiscuous Proteins

  • Menachem Fromer,

    Affiliation: School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel

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  • Julia M. Shifman mail

    jshifman@cc.huji.ac.il

    Affiliation: Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

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  • Published: December 24, 2009
  • DOI: 10.1371/journal.pcbi.1000627

About the Authors

Menachem Fromer
School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
Julia M. Shifman
Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

Corresponding Author

Email: jshifman@cc.huji.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MF JMS. Performed the experiments: MF JMS. Analyzed the data: MF JMS. Contributed reagents/materials/analysis tools: MF JMS. Wrote the paper: MF JMS.