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Research Article

Identification of Networks of Co-Occurring, Tumor-Related DNA Copy Number Changes Using a Genome-Wide Scoring Approach

  • Christiaan Klijn,

    Affiliations: Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands, Information and Communication Theory Group, Delft University of Technology, Delft, The Netherlands

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  • Jan Bot,

    Affiliations: Information and Communication Theory Group, Delft University of Technology, Delft, The Netherlands, Netherlands Bioinfomatics Centre, Nijmegen, The Netherlands

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  • David J. Adams,

    Affiliation: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Marcel Reinders,

    Affiliation: Information and Communication Theory Group, Delft University of Technology, Delft, The Netherlands

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  • Lodewyk Wessels mail,

    l.wessels@nki.nl (LW); j.jonkers@nki.nl (JJ)

    Affiliations: Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands, Information and Communication Theory Group, Delft University of Technology, Delft, The Netherlands

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  • Jos Jonkers mail

    l.wessels@nki.nl (LW); j.jonkers@nki.nl (JJ)

    Affiliation: Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Published: January 01, 2010
  • DOI: 10.1371/journal.pcbi.1000631

About the Authors

Christiaan Klijn, Lodewyk Wessels, Jos Jonkers
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Christiaan Klijn, Jan Bot, Marcel Reinders, Lodewyk Wessels
Information and Communication Theory Group, Delft University of Technology, Delft, The Netherlands
Jan Bot
Netherlands Bioinfomatics Centre, Nijmegen, The Netherlands
David J. Adams
Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CK MR LW JJ. Performed the experiments: CK JB. Analyzed the data: CK MR LW JJ. Contributed reagents/materials/analysis tools: DJA. Wrote the paper: CK MR LW JJ.