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Research Article

Quantitative Modeling of GRK-Mediated β2AR Regulation

  • Sharat J. Vayttaden,

    Affiliations: Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America, Cell and Regulatory Biology Program, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, Texas, United States of America

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  • Jacqueline Friedman,

    Affiliation: Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America

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  • Tuan M. Tran,

    Affiliation: Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America

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  • Thomas C. Rich,

    Affiliation: Department of Pharmacology, College of Medicine and Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States of America

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  • Carmen W. Dessauer,

    Affiliation: Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America

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  • Richard B. Clark mail

    Richard.B.Clark@uth.tmc.edu

    Affiliation: Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America

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  • Published: January 22, 2010
  • DOI: 10.1371/journal.pcbi.1000647

About the Authors

Sharat J. Vayttaden, Jacqueline Friedman, Tuan M. Tran, Carmen W. Dessauer, Richard B. Clark
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America
Sharat J. Vayttaden
Cell and Regulatory Biology Program, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, Texas, United States of America
Thomas C. Rich
Department of Pharmacology, College of Medicine and Center for Lung Biology, University of South Alabama, Mobile, Alabama, United States of America

Corresponding Author

Email: Richard.B.Clark@uth.tmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJV TCR CWD RBC. Performed the experiments: JF TMT. Analyzed the data: SJV TMT RBC. Contributed reagents/materials/analysis tools: TMT RBC. Wrote the paper: SJV RBC. Wrote the code, performed theoretical experiments: SJV. Wrote the base code: TCR. Edited the manuscript: JF TMT TCR CWD.