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Research Article

Blurring of High-Resolution Data Shows that the Effect of Intrinsic Nucleosome Occupancy on Transcription Factor Binding is Mostly Regional, Not Local

  • Wee Siong Goh,

    Affiliation: Computational and Systems Biology, Genome Institute of Singapore, Singapore

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  • Yuriy Orlov,

    Affiliation: Computational and Systems Biology, Genome Institute of Singapore, Singapore

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  • Jingmei Li,

    Affiliation: Computational and Systems Biology, Genome Institute of Singapore, Singapore

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  • Neil D. Clarke mail

    clarken@gis.a-star.edu.sg

    Affiliation: Computational and Systems Biology, Genome Institute of Singapore, Singapore

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  • Published: January 22, 2010
  • DOI: 10.1371/journal.pcbi.1000649

About the Authors

Wee Siong Goh, Yuriy Orlov, Jingmei Li, Neil D. Clarke
Computational and Systems Biology, Genome Institute of Singapore, Singapore

Corresponding Author

Email: clarken@gis.a-star.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NDC. Performed the experiments: JL. Analyzed the data: WSG YO NDC. Wrote the paper: WSG NDC. Helped edit the paper: YO.