Advertisement
Research Article

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

  • Silpa Suthram,

    Affiliations: Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, United States of America, Department of Pediatrics, Stanford University, Stanford, California, United States of America, Lucile Packard Children's Hospital, Palo Alto, California, United States of America

    X
  • Joel T. Dudley,

    Affiliations: Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, United States of America, Department of Pediatrics, Stanford University, Stanford, California, United States of America, Lucile Packard Children's Hospital, Palo Alto, California, United States of America

    X
  • Annie P. Chiang,

    Affiliations: Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, United States of America, Department of Pediatrics, Stanford University, Stanford, California, United States of America, Lucile Packard Children's Hospital, Palo Alto, California, United States of America

    X
  • Rong Chen,

    Affiliations: Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, United States of America, Department of Pediatrics, Stanford University, Stanford, California, United States of America, Lucile Packard Children's Hospital, Palo Alto, California, United States of America

    X
  • Trevor J. Hastie,

    Affiliation: Department of Statistics, Stanford University, Stanford, California, United States of America

    X
  • Atul J. Butte mail

    abutte@stanford.edu

    Affiliations: Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, United States of America, Department of Pediatrics, Stanford University, Stanford, California, United States of America, Lucile Packard Children's Hospital, Palo Alto, California, United States of America

    X
  • Published: February 05, 2010
  • DOI: 10.1371/journal.pcbi.1000662

About the Authors

Silpa Suthram, Joel T. Dudley, Annie P. Chiang, Rong Chen, Atul J. Butte
Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, United States of America
Silpa Suthram, Joel T. Dudley, Annie P. Chiang, Rong Chen, Atul J. Butte
Department of Pediatrics, Stanford University, Stanford, California, United States of America
Silpa Suthram, Joel T. Dudley, Annie P. Chiang, Rong Chen, Atul J. Butte
Lucile Packard Children's Hospital, Palo Alto, California, United States of America
Trevor J. Hastie
Department of Statistics, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: abutte@stanford.edu

Competing Interests

Atul J. Butte is or has served as a scientific advisor and/or consultant to NuMedii, Genstruct, Prevendia, Tercica, Eli Lilly and Company, and Johnson & Johnson.

Author Contributions

Conceived and designed the experiments: SS. Performed the experiments: SS. Analyzed the data: SS. Contributed reagents/materials/analysis tools: SS. Wrote the paper: SS. Assembled the annotated microarray experiments from GEO: JTD. Compiled the drug data from DrugDex: APC. Compiled the Disease Gene List: RC. Offered critical guidance in the statistical approach: TJH. Conceived the study: AB.