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Research Article

A Variant of TNFR2-Fc Fusion Protein Exhibits Improved Efficacy in Treating Experimental Rheumatoid Arthritis

  • Tong Yang equal contributor,

    equal contributor Contributed equally to this work with: Tong Yang, Zheng Wang

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Zheng Wang equal contributor,

    equal contributor Contributed equally to this work with: Tong Yang, Zheng Wang

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Fang Wu,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Jingwei Tan,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Yijun Shen,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Erguang Li,

    Affiliation: School of Medicine, Nanjing University, Nanjing, China

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  • Jingzhi Dai,

    Affiliation: Shanghai Institute of Pharmaceutical Industry, Shanghai, China

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  • Ronghai Shen,

    Affiliation: Shanghai Institute of Pharmaceutical Industry, Shanghai, China

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  • Gang Li,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Jinsong Wu,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Luochun Wang,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Haibo Wang,

    Affiliation: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China

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  • Yanjun Liu mail

    yjliu@fd-zj.com

    Affiliations: Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China, Taizhou Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Taizhou City, Jiangsu Province, China

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  • Published: February 05, 2010
  • DOI: 10.1371/journal.pcbi.1000669

About the Authors

Tong Yang, Zheng Wang, Fang Wu, Jingwei Tan, Yijun Shen, Gang Li, Jinsong Wu, Luochun Wang, Haibo Wang, Yanjun Liu
Department of Genetic Engineering Development, Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Shanghai, China
Erguang Li
School of Medicine, Nanjing University, Nanjing, China
Jingzhi Dai, Ronghai Shen
Shanghai Institute of Pharmaceutical Industry, Shanghai, China
Yanjun Liu
Taizhou Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd., Taizhou City, Jiangsu Province, China

Corresponding Author

Email: yjliu@fd-zj.com

Competing Interests

Tong Yang, Zheng Wang, Fang Wu, Jingwei Tan, Yijun Shen, Gang Li, Jinsong Wu, Luochun Wang, Haibo Wang and Yanjun Liu are employees of Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Yanjun Liu is also an employee of Taizhou Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Taizhou Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. is a wholly-owned subsidiary company of Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Author Contributions

Conceived and designed the experiments: TY ZW HW YL. Performed the experiments: TY ZW FW JT YS JD RS GL JW YL. Analyzed the data: TY ZW FW YS EL JD RS JW LW YL. Contributed reagents/materials/analysis tools: TY JT EL JD RS LW HW YL. Wrote the paper: TY ZW YS EL YL. Collected references: GL. Organized the research: HW.